ABSTRACT
Introducción: La infertilidad afecta hasta un 15 por ciento de las parejas en edad reproductiva en el mundo y es uno de los factores que inciden en la baja natalidad de Cuba. Antes del 2016 no existían consultas de infertilidad en todos los municipios y era bajo el número de embarazos logrados, lo que motivó la decisión de extenderlas a todos los municipios del país. Objetivo: Describir los resultados de las consultas municipales de infertilidad en los primeros cuatro años de su implementación (2017-2020). Métodos: Estudio observacional transversal de casos, atendidos en las 82 consultas municipales de infertilidad existentes antes del 2016 y después de su generalización a todos los municipios del país. Resultados: En las consultas municipales han sido atendidas 81,3 por ciento de las parejas infértiles que lo demandan, se incrementó el número de consultas ofrecidas de 24 215 en el año 2016 a 140 183 en el 2020. En ese período se elevó en 10 por ciento los embarazos obtenidos, 63,5 por ciento de los logrados en todos los niveles de atención. Conclusiones: Las consultas municipales incrementaron sus resultados entre el año 2017 al 2020 y los nacimientos obtenidos pueden ser considerados como una contribución del sector salud a reducir la baja natalidad que experimenta el país(AU)
Introduction: Infertility affects up to 15percent of couples of reproductive age in the world and is one of the factors affecting the low birth rate in Cuba. Before 2016, infertility consultations did not exist in all municipalities and the number of pregnancies achieved was low, which motivated the decision to extend them to all municipalities in the country. Aim: To describe the results of municipal infertility consultations in the first four years of their implementation (2017-2020). Methods: Cross-sectional observational study of cases, attended in the 82 municipal infertility consultations existing before 2016 and after their generalization to all municipalities in the country. Results: 81.3percent of the infertile couples requesting treatment were attended in the municipal consultations. The number of consultations offered increased from 24 215 in 2016 to 140 183 in 2020. In that period, pregnancies obtained increased by 10 percent, 63.5 percent of those achieved at all levels of care. Conclusions: Municipal consultations increased their results from 2017 to 2020 and the births obtained can be considered as a contribution of the health sector to reduce the low birth rate experienced by the country(AU)
Subject(s)
Humans , Male , Female , Birth Rate/trends , Infertility/epidemiology , Cross-Sectional Studies , Observational StudyABSTRACT
ObjectiveTo compare the effects of two different insemination methods， conventional in vitro fertilization （IVF） and intracytoplasmic sperm injection （ICSI）， on pregnancy outcomes in patients with frozen-thawed D6（day 6） blastocyst transfer. MethodsA retrospective cohort study was conducted to analyze the clinical data of patients with thawed D6 blastocyst transfer between January 2018 and April 2020 at the Fertility Center of the Third Hospital of Sun Yat-sen University， divided into conventional IVF group （446 cycles ） and ICSI fertilization group （200 cycles） according to the fertilization method. Patients were divided into those with a history of D5（day 5） blastocyst transfer and those without. The patients’ general characteristics， blastocyst quality， and pregnancy outcomes of the two groups were compared. ResultsBMI， years of infertility， and basal FSH were not statistically significant in the IVF and ICSI groups （P > 0.05）. Regardless of the history of D5 transfer， patients in the ICSI group were younger than those in the IVF group （P < 0.001）， the proportion of primary infertility was significantly higher in the ICSI group （P < 0.001）， and the number of oocytes obtained and the number of normally fertilized oocytes in the ICSI group were higher than those in the conventional IVF fertilization group （P < 0.001）. The proportion of stage V and Ⅵ blastocysts was significantly higher in the conventional IVF group than in the ICSI group （21.6 % vs. 3.14 %， P < 0.001）. High-quality blastocysts with an ICM score of A were significantly higher in the ICSI group than in the IVF group （23.8 % vs. 14.3 %， P = 0.01）. The HCG-positive and clinical pregnancy rates were significantly higher in the ICSI group than in the IVF group （65.5 % vs. 48.4 %， P < 0.001； 56 % vs. 41.3 %， P = 0.001）， and embryo implantation and live birth rates were also higher in the ICSI group than in the conventional IVF group （43.8 % vs. 30.9 %， P < 0.001； 43.0 % vs. 31.8 %， P = 0.006）. After correcting for age and number of oocytes obtained between the two groups， the clinical pregnancy rate was still significantly higher in the ICSI group than in the conventional IVF group （OR： 1.590， 95 % CI： 1.030， 2.455， P = 0.036）. Infant birth weight was lower in the ICSI group than in the IVF group （P = 0.016）， and the differences in preterm birth rate， sex ratio， and mode of delivery were not statistically significant between the two groups. ConclusionsClinical pregnancy and live birth rates after thawing and transfer of D6 blastocysts fertilized by ICSI are higher than those of D6 blastocysts fertilized by conventional IVF， which may be related to the different factors contributing to the slow development of blastocysts in patients who received different fertilization methods. The relatively good pregnancy outcome after the transfer of thawed D6 blastocysts fertilized by ICSI may compensate to some extent for the difference in pregnancy outcome due to the relatively slow blastocyst development and a relatively higher proportion of D6 blastocysts after ICSI fertilization in male infertility patients.
ABSTRACT
ObjectivesTo assess the correlation between blastocyst morphology score， serum human chorionic gonadotropin β subunit （β-hCG） levels on day 12 after transfer and live birth outcomes among cycles tested HCG-positive after thawed single blastocyst transfer； to analyze the predictive value of serum β-hCG levels on live birth. MethodsWe reviewed the data of 519 frozen-thawed single blastocyst transfer cycles （FET） that had been tested HCG-positive from January 2016 to May 2020 at our IVF center. These FET cycles were firstly divided into 4 groups （AA， AB， BA， and BB） according to Gardner's grading system of inner cell mass （ICM） and trophectoderm cell （TE）， and then 4 groups （stages 3， 4， 5 and 6） according to the degree of blastocyst expansion. Serum β-hCG concentrations on day 12 after transfer and live birth rates were compared among groups transferred with different blastocysts grading and expansion stage. The relationship between Gardner’s grading or expansion stage of blastocysts and serum β-hCG levels was determined by correlation test， and ROC curves were plotted to determine the threshold values of serum β-hCG for predicting live birth. Results（1） The serum β-hCG concentration in the AA group and AB group on the 12th day after the transfer was significantly higher than that in the BB group （P <0.001， P <0.001）. However， there was no significant difference in the live birth rate when different ICM/TE-graded blastocysts were transferred （P = 0.120）. There were no significant differences in serum β-hCG concentration on day 12 after transfer and live birth rate among blastocysts with different expansion stages （P = 0.091， P = 0.557）. （2） There was a significant weak correlation between blastocyst ICM/TE grading and serum β-hCG concentration on day 12 （rs = -0.221， P <0.001）， and even after controlling for confounding factors （ rs = -0.228， P <0.001）；There was no significant correlation between blastocyst’s expansion stage and serum β-hCG concentration on day 12 after the transfer （rs = -0.052， P = 0.240）， and the association remained insignificant after controlling for confounding factors （rs = -0.029， P = 0.508）. （3） ROC curve analysis showed that the cut-off value for predicting live birth by serum β-hCG on day 12 was 657.5 mU/mL （P < 0.001）. ConclusionsNeither the ICM/TE grade nor the expansion stage of blastocysts affect the live birth rate，there is significant difference in the level of β-hCG produced by blastocyst with different ICM/TE grade；Our results suggest that early serum β-hCG level can predict live birth.
ABSTRACT
Abstract Background Infertility is caused by heterogeneous risks, but most of them are unexplained. The sperm DNA Fragmentation Index (DFI) was increasingly acknowledged as a parameter for the evaluation of male infertility. This study aimed to investigate the association between sperm DFI and laboratory and clinical outcomes in a population with unexplained infertility. Methods The clinical data of an infertile population was collected for the selection of reproductive patients with unexplained infertility. The authors classified the patients with normal sperm parameters in a control group (DFI < 25%) and an observation group (DFI ≥ 25%) and compared the difference in basal characteristics, laboratory, and clinical outcomes between the two groups. The authors conducted a correlation analysis to examine the relationship between DFI and the number of D3 good-quality embryos, as well as the clinical pregnancy rate and live birth rate. A total of 176 cases were enrolled in the retrospective study. Results The observation group (n = 88) showed advanced male age, lower sperm concentration, progressive motility, and morphology assessment than the control group. In addition, lower No. of D3 good-quality embryos, clinical pregnancy rate, and the live birth rate were shown in the observation group. A negative correlation between the DFI and No. of D3 good-quality embryos (rs = -0.347, p < 0.001) or live birth rate (rs = -0.185, p = 0.028) was shown. Conclusions Sperm DFI was a good indicator for the prediction of D3 good-quality embryos in unexplained infertility couples, but it did not provide sufficient information regarding clinical pregnancy outcome but live pregnancy outcome.
ABSTRACT
【Objective】 To observe the effects of paternal age on the pregnancy outcomes in frozen embryo transfer (FET) cycles. 【Methods】 The clinical data of two groups after propensity score matching (PSM) were retrospectively analyzed, including 738 cycles in the 0.05). The clinical pregnancy rate (52.2%vs. 67.2%) and live birth rate (41.1% vs. 57.2%) decreased in the 40-60 year group compared with those in the 0.05). 【Conclusion】 Advanced paternal age decreases clinical pregnancy rate and live birth rate.
ABSTRACT
OBJECTIVES@#To identify, examine and summarize the available evidence on the effectiveness and safety of acupuncture for in vitro fertilisation (IVF) outcomes.@*METHODS@#Eight electronic databases, including PubMed, EMBASE, Cochrane Database of Systematic Review, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Wanfang Database, Chinese Biomedical Database and VIP Database, were searched, supplemented by manual searches. Two researchers independently conducted the literature screening, data extraction, and methodological quality assessments. A narrative description was provided to show the general information and specific characteristics of the included studies. A bubble plot was used to visually display the overall effects of acupuncture on IVF outcomes.@*RESULTS@#Eighty-two studies were identified, including 64 primary studies and 18 systematic reviews. Transcutaneous electrical acupoint stimulation, electric acupuncture and manual acupuncture were applied in most studies and compared with no acupuncture, sham acupuncture and placebo acupuncture control groups. Sixty-three (98.4%) primary studies reported clinical pregnancy rate, and positive effects of acupuncture were found in 34 studies (54.0%). Live birth rate was reported in only 18 (28.1%) primary studies, of which 10 (55.6%) showed positive results. In addition, only 8 and 2 systematic reviews showed that acupuncture could increase clinical pregnancy events and live birth events, respectively. However, none of these reviews was of high methodological quality.@*CONCLUSIONS@#Available evidence suggests that acupuncture therapy could improve clinical pregnancy rates. However, whether acupuncture could increase live birth events was difficult to determine based on the few studies that have reported this outcome indicator. Furthermore, the methodological quality of most systematic reviews was assessed as critically low or low. Studies with a rigorous design and standardized implementation should be performed to refine the available evidence.
Subject(s)
Female , Humans , Pregnancy , Acupuncture Therapy/methods , China , Fertilization in Vitro , Pregnancy RateABSTRACT
Resumen: OBJETIVO: Determinar la frecuencia de embarazos mediante la tasa de nacidos vivos en el grupo etario de 15 a 19 años y su asociación con el Índice de Desarrollo Humano (2016 a 2021). MATERIALES Y MÉTODOS: Estudio observacional, ecológico, exploratorio y correlacional efectuado con base en la información del Sistema de Registro del Certificado de Nacido Vivo en Línea y el Índice de Desarrollo Humano, que son datos por departamento, provincias y municipios. Se incluyeron todas las mujeres residentes en Perú con un recién nacido entre 2016 y 2021. Los datos registrados fueron: total de recién nacidos por departamento, región, provincia y distrito, divididos por grupos etarios de 15 a 19 años. Para el análisis de los datos se utilizaron regresión lineal y correlación de Pearson. RESULTADOS: En el periodo de estudio se registraron 2,843,903 nacimientos de los que 324,654 (11.41%) correspondieron a mujeres menores de 20 años. En el 2017 se registró la más alta cantidad de nacimientos en este grupo etario (n = 58,841). En 2016 el porcentaje más alto de nacimientos de hijos de adolescentes fue de 12.36% y el más bajo (10.51%) se registró en el 2020. CONCLUSIÓN: El porcentaje de adolescentes embarazadas disminuyó levemente en los últimos años, aunque hubo un ligero aumento en el 2021, sobre todo en la región de la selva, que es la de mayor proporción en comparación con las otras. El índice de desarrollo humano provincial y municipal está inversamente relacionado con la proporción de embarazos en adolescentes.
Abstract OBJECTIVE: To determine the frequency of pregnancies through the live birth rate in the 15-19 age group and its association with the Human Development Index (2016 to 2021). MATERIALS AND METHODS: Observational, ecological, exploratory, and correlational study carried out based on information from the Online Live Birth Certificate Registration System and the Human Development Index, which are data by department, provinces and municipalities. All women residing in Peru with a newborn between 2016 and 2021 were included. The data recorded were total newborns by department, region, province and district, divided by age groups from 15 to 19 years. Linear regression and Pearson correlation were used for data analysis. RESULTS: In the study period, 2,843,903 births were registered, of which 324,654 (11.41%) corresponded to women under 20 years of age. In 2017, the highest number of births was recorded in this age group (n = 58,841). In 2016, the highest percentage of births to teenagers was 12.36% and the lowest (10.51%) was recorded in 2020. CONCLUSION: The percentage of pregnant adolescents decreased slightly in recent years, although there was a slight increase in 2021, especially in the jungle region, which has the highest proportion compared to the others. The provincial and municipal human development index is inversely related to the proportion of teenage pregnancy.
ABSTRACT
Introducción: A nivel mundial la tasa de natalidad desde las últimas décadas ha venido en declive, por lo que adquiere relevancia investigar sus cambios. Objetivos: Cuantificar la tendencia de nacimientos en Chile según rango etario de la madre y sexo biológico del recién nacido en el periodo 2015-2020. Metodología: Se realizó un estudio observacional y ecológico, con los datos obtenidos del banco mundial y DEIS, para la población y nacimientos respectivamente. Los datos se dividieron según las edades maternas en tres grupos: <18 años, 18-34 años y ≥ 35 años. No se requirió comité de ética debido a que no se interviene con personas. Los autores no presentan conflicto de interés. Resultados: Se observó una disminución de los nacimientos del 22,6%, pasando de 244.626 el 2015 a 189.250 el 2020. Los nacimientos en el grupo etario de madres menores a 18 años disminuyeron un 82,13%, reduciéndose de 17.505 a 3.129, el rango de edad materna correspondiente al segundo grupo de 18 a 34 años, ubicó la mayor cantidad de nacimientos, manteniéndose alrededor de un 77,75% (neto), el rango ≥ 35 años, presentó un alza de un 17%, aumentando de 34.648 nacimientos a 40.539. Discusión: En Chile hay un descenso en los nacimientos dado a que la maternidad se está postergando, lo cual puede deberse a la educación sexual implementada en el país y la mayor participación de mujeres en ámbito laboral, esto sugiere una transición de una demografía estable a una regresiva.
Introduction: The birth rate has been declining worldwide since the last decades, so it is important to investigate its changes. Objectives: To quantify the trend of births in Chile according to age range of the mother and biological sex of the newborn in the period 2015-2020. Methodology: An observational and ecological study was conducted, with data obtained from the World Bank and DEIS, for population and births respectively. Data were divided according to maternal ages into three groups: <18 years, 18-34 years and ≥ 35 years. No ethics committee was required due to the fact that we did not intervene with individuals. The authors have no conflict of interest. Results: A decrease in births of 22.6% was observed, from 244,626 in 2015 to 189,250 in 2020. Births in the age group of mothers under 18 years decreased by 82.13%, decreasing from 17,505 to 3,129, the maternal age range corresponding to the second group from 18 to 34 years, located the highest number of births, remaining around 77.75% (net), the range ≥ 35 years, presented a rise of 17%, increasing from 34. Discussion: In Chile there is a decrease in births due to the fact that motherhood is being postponed, which may be due to the sexual education implemented in the country and the greater participation of women in the labor market, suggesting a transition from a stable demography to a regressive one.
Subject(s)
Humans , Female , Pregnancy , Child, Preschool , Child , Adolescent , Adult , Young Adult , Birth Rate/trends , Maternal Age , Chile/epidemiologyABSTRACT
Background@#Pre-implantation Genetic Testing for Aneuploidy (PGT-A) has enabled IVF specialists to screen embryos for abnormalities in chromosome number and structure. Subsequently, healthy embryos are selected for transfer, decreasing the rate of spontaneous miscarriages and improving pregnancy outcomes. In spite of this, almost only half of the PGTdetermined euploid embryos result in a pregnancy. @*Objective@#This study aimed to determine what other factors among euploid embryo transfers will have an association with successful implantation and live birth. @*Methods@#This study retrospectively analyzed 159 IVF-PGS cycles performed in CARMI SLMCGC from January 2017 to December 2019. Of these, a total of 231 euploid embryos (86 single embryo transfers and 73 double embryo transfers) were assessed. The relationship of eight predictive variables (maternal age, maternal BMI, etiology of infertility, history of failed IVF, blastocyst expansion stage, ICM grade, TE grade and endometrial thickness on transfer) with regard to the outcome of successful implantation and live birth among single or double euploid blastocyst transfers were determined via logistic regression analysis. @*Results@#Overall, the implantation rate was significantly lower when using B-grade ICM or C-grade ICM blastocysts as compared to A-grade ICM blastocysts (OR 0.54, 95% CI 0.356- 0.815, p = 0.003). With regard to live birth rate, the success of transfer is statistically lower when using a B-grade or C-grade ICM blastocysts as compared to A-grade ICM blastocysts (OR 0.55, CI 0.354-0.863, p = 0.009). Other predictive factors such as maternal age, maternal BMI, etiology of infertility, number of previous IVF, blastocyst expansion stage, trophectoderm grade and endometrial thickness had no apparent effect on the outcome of implantation and live birth. @*Conclusion@#Present study results suggest that only the ICM grade of euploid blastocysts correlates with implantation and live birth in IVF-FET cycles. Therefore, the selection of euploid blastocysts based on the presence of a higher grade ICM is the most predictive factor that determines success among those undergoing IVF with PGT-A.
Subject(s)
Live Birth , Genetic TestingABSTRACT
Studies have explored the assisted reproductive technology (ART) outcomes of Y-chromosome azoospermia factor c (AZFc) microdeletions, but the effect of sperm source on intracytoplasmic sperm injection (ICSI) remains unknown. To determine the ART results of ICSI using testicular sperm and ejaculated sperm from males with AZFc microdeletions, we searched Embase, Web of Science, and PubMed to conduct a systematic review and meta-analysis. The first meta-analysis results for 106 cycles in five studies showed no significant differences in the live birth rate between the testicular sperm group and the ejaculated sperm group (risk ratio: 0.97, 95% confidence interval [CI]: 0.73-1.28, P = 0.82). The second meta-analysis of 106 cycles in five studies showed no difference in the abortion rate between the testicular sperm group and ejaculated sperm group (risk ratio: 1.06, 95% CI: 0.54-2.06, P = 0.87). The third meta-analysis of 386 cycles in seven studies showed no significant difference in clinical pregnancy rates between the testicular sperm group and the ejaculated sperm group (risk ratio: 1.24, 95% CI: 0.66-2.34, P = 0.50). Inevitable heterogeneity weakened our results. However, our results indicated that testicular sperm and ejaculated sperm yield similar ART outcomes, representing a meaningful result for clinical treatment. More properly designed studies are needed to further confirm our conclusions.
ABSTRACT
Objective To explore the impact of the two-child policy on the fertility level of residents in Yangpu District. Methods Birth registry data were collected from the residents of Yangpu District in Shanghai during January 2015 to December 2018 for the analysis of birth characteristics and its variation after the two-child policy implementation. Results The total fertility rate was higher than 1 only in 2016 that was 1.04, whereas it was about 0.8 in other three years. The number of the second child increased which was inspired by the policy. However, the increment in the number of second child was far less than the decrease in the first child. From 2015 through 2018, the proportion of second children in the total births with local household registration accounted for 18.84%, 20.03%, 26.29% and 24.35%, respectively. From January 2015 to August 2016, the proportion of second children was on the rise slowly, in which the annual percent change(APC)value was 0.34%(P > 0.05). From September 2016 to May 2017, the proportion of second children had shown an obvious increase, and the APC value was 3.97%(P < 0.05). From June 2017 to December 2018, the proportion of second children was on a downward trend, in which the APC value was -0.97%(P < 0.05). Conclusion Favorable fertility policy may not reverse the fertility level in Yangpu District, which remains at a very low level.
ABSTRACT
Objective@#To evaluate the effect of transcutaneous electrical acupoint stimulation (TEAS) on the pregnancy outcomes of in vitro fertilization-embryo transfer (IVF-ET) based on the available clinical evidence.@*METHODS@#We searched PubMed, MEDLINE, EMBASE, Cochrane Library, CNKI, VIP, CBM and Wanfang Database up to February 2021 for published randomized controlled trials (RCT) relevant to TEAS for the improvement of the pregnancy outcomes of IVF-ET. We performed literature screening, data extraction and quality evaluation according to the inclusion and exclusion criteria, followed by a meta-analysis with the RevMan 5.3 software.@*RESULTS@#A total of 2 206 cases of IVF-ET from 9 RCTs were included, 1 018 in the TEAS group and 1 188 in the control. The clinical pregnancy rate was significantly higher in the TEAS than in the mock TEAS and non-TEAS control groups (RR = 1.85, 95% CI: 1.42－2.42, P < 0.001; RR = 1.23, 95% CI: 1.10－1.39, P = 0.0004), and so was it before and after oocyte retrieval (RR = 1.50, 95% CI: 1.03－2.17, P = 0.03; RR = 1.47, 95% CI: 1.12－1.92, P = 0.005). The TEAS group also showed dramatically improved embryo implantation rate (RR = 1.49, 95% CI: 1.24－1.79, P < 0.0001) and live birth rate (RR = 1.44, 95% CI: 1.04－1.98, P = 0.03) compared with the control.@*CONCLUSIONS@#As a safe and non-invasive treatment, TEAS can significantly improve the pregnancy outcomes of IVF-ET, with definite effectiveness. /.
Subject(s)
Female , Humans , Pregnancy , Acupuncture Points , Embryo Transfer , Fertilization in Vitro , Pregnancy Outcome , Randomized Controlled Trials as TopicABSTRACT
ABSTRACT Objective: To analyze the temporal trends in the fertility rate, proportion of antenatal consultations and caesarean sections in Brazilian adolescents aged 15 to 19, between 2000 and 2015. Methods: The fertility rate, proportion of prenatal consultations and proportion of routes of birth were calculated using data from DATASUS. The trend analysis was performed using the Prais-Winsten regression model and the annual percentage change. Results: There was a trend of reduction of 3.5% per year in the fertility rate among adolescents (p<0.05), in addition to an increasing trend of 6% per year in the proportion of more than six antenatal consultations (p <0.0001) and an increasing trend of 6.8% per year in the proportion of caesarean sections (p<0.0001). Conclusion: Despite the decreasing trend in fertility rates among Brazilian adolescents, they remain high. Also noteworthy is the growing trend for caesarean sections, even with improved access to antenatal care.
RESUMEN Objetivo: Analizar las tendencias temporales de la tasa de fertilidad, proporción de consultas de prenatal y cesarianas en adolescentes brasileñas de 15 a 19 años, entre 2000 y 2015. Métodos: La tasa de fertilidad, proporción de consultas de prenatal y proporción de vías de nacimiento fueran calculadas con datos del DATASUS. Análisis de tendencia realizada utilizándose modelo de regresión de Prais-Winsten y la tasa de variación media anual. Resultados: Observó tendencia de reducción de 3,5% al año de la tasa de fertilidad entre las adolescentes (p<0,05), además de tendencia creciente de 6% al año de la proporción de más de seis consultas de prenatal (p<0,0001) y tendencia creciente de 6,8% al año de la proporción de cesarianas (p<0,0001). Conclusión: Aunque la tendencia decreciente de la tasa de fertilidad en adolescentes brasileñas, ellas aún permanecen elevadas. Destaca también la tendencia creciente de cesarianas, mismo con la mejoría del acceso al prenatal.
RESUMO Objetivo: Analisar as tendências temporais da taxa de fertilidade, proporção de consultas de prénatal e cesarianas em adolescentes brasileiras de 15 a 19 anos, entre 2000 e 2015. Métodos: A taxa de fertilidade, proporção de consultas de pré-natal e proporção de vias de nascimento foram calculadas com dados do DATASUS. A análise de tendência foi realizada utilizando-se o modelo de regressão de Prais-Winsten e a taxa de variação média anual. Resultados: Observou-se tendência de redução de 3,5% ao ano da taxa de fertilidade entre as adolescentes (p<0,05), além de tendência crescente de 6% ao ano da proporção de mais de seis consultas de pré-natal (p<0,0001) e tendência crescente de 6,8% ao ano da proporção de cesarianas (p<0,0001). Conclusão: Apesar da tendência decrescente da taxa de fertilidade nas adolescentes brasileiras, elas ainda permanecem elevadas. Destaca-se também a tendência crescente de cesarianas, mesmo com a melhoria do acesso ao pré-natal.
ABSTRACT
ABSTRACT Objective: To analyze the temporal trends in the fertility rate, proportion of antenatal consultations and caesarean sections in Brazilian adolescents aged 15 to 19, between 2000 and 2015. Methods: The fertility rate, proportion of prenatal consultations and proportion of routes of birth were calculated using data from DATASUS. The trend analysis was performed using the Prais-Winsten regression model and the annual percentage change. Results: There was a trend of reduction of 3.5% per year in the fertility rate among adolescents (p<0.05), in addition to an increasing trend of 6% per year in the proportion of more than six antenatal consultations (p <0.0001) and an increasing trend of 6.8% per year in the proportion of caesarean sections (p<0.0001). Conclusion: Despite the decreasing trend in fertility rates among Brazilian adolescents, they remain high. Also noteworthy is the growing trend for caesarean sections, even with improved access to antenatal care.
RESUMEN Objetivo: Analizar las tendencias temporales de la tasa de fertilidad, proporción de consultas de prenatal y cesarianas en adolescentes brasileñas de 15 a 19 años, entre 2000 y 2015. Métodos: La tasa de fertilidad, proporción de consultas de prenatal y proporción de vías de nacimiento fueran calculadas con datos del DATASUS. Análisis de tendencia realizada utilizándose modelo de regresión de Prais-Winsten y la tasa de variación media anual. Resultados: Observó tendencia de reducción de 3,5% al año de la tasa de fertilidad entre las adolescentes (p<0,05), además de tendencia creciente de 6% al año de la proporción de más de seis consultas de prenatal (p<0,0001) y tendencia creciente de 6,8% al año de la proporción de cesarianas (p<0,0001). Conclusión: Aunque la tendencia decreciente de la tasa de fertilidad en adolescentes brasileñas, ellas aún permanecen elevadas. Destaca también la tendencia creciente de cesarianas, mismo con la mejoría del acceso al prenatal.
RESUMO Objetivo: Analisar as tendências temporais da taxa de fertilidade, proporção de consultas de prénatal e cesarianas em adolescentes brasileiras de 15 a 19 anos, entre 2000 e 2015. Métodos: A taxa de fertilidade, proporção de consultas de pré-natal e proporção de vias de nascimento foram calculadas com dados do DATASUS. A análise de tendência foi realizada utilizando-se o modelo de regressão de Prais-Winsten e a taxa de variação média anual. Resultados: Observou-se tendência de redução de 3,5% ao ano da taxa de fertilidade entre as adolescentes (p<0,05), além de tendência crescente de 6% ao ano da proporção de mais de seis consultas de pré-natal (p<0,0001) e tendência crescente de 6,8% ao ano da proporção de cesarianas (p<0,0001). Conclusão: Apesar da tendência decrescente da taxa de fertilidade nas adolescentes brasileiras, elas ainda permanecem elevadas. Destaca-se também a tendência crescente de cesarianas, mesmo com a melhoria do acesso ao pré-natal.
ABSTRACT
ABSTRACT Objective: In humans, males' births exceed females' births. This ratio is conventionally referred to as M/F and is used to denote male births divided by total births. This ratio is influenced by a large number of factors and has been shown to exhibit seasonality. This study was carried out in order to ascertain whether seasonal variation in M/F exists in the United States of America and whether such variations are influenced by race. Materials and Methods: Data on births by gender and race from 2003 to 2013 were obtained from Centres for Disease Control and Prevention Wonder section as four races: White, Black/African American, Asian/Pacific Islander and American Indian/Alaska Native. ANOVA and ARIMA tests were carried out. Results: This study analysed 45 103 146 live births (M/F 0.51182) over 2003 to 2013. M/F was highest in Asian/Pacific Islander (p < < 0.0001), followed by White (p = 0.002), American Indian/Alaska Native (p = 0.04) and Black/African American. Significant seasonality was present overall, with a peak in June, for Whites more than Black/African American. Conclusion: Parental stress lowers M/F, and lower M/F found in Black/African and American Indian/Alaskan births may be stress related. The dampened seasonality noted in Black/African American births may also be due to this phenomenon. More males were born in spring, as in other species, with interesting inter-racial differences.
Subject(s)
Humans , Male , Female , Infant, Newborn , Seasons , Sex , Birth Rate , Racial GroupsABSTRACT
Objective:To investigate the influence of age on the fresh cycle live birth rate in patients with poor ovarian response in different controlled ovarian hyperstimulation groups.Methods:The clinical data of 3 342 patients in The First Affiliated Hospital of Zhengzhou University from February 2014 to November 2018 were retrospectively collected, including early-follicular phase long-acting gonadotropin-releasing hormone (GnRH) agonist long protocol group (1 375 cases), mid-luteal phase short-acting GnRH agonist long protocol group (1 161 cases) and GnRH antagonist protocol group (806 cases); each group was divided into 4 subgroups according to age: ≤30 years, 31－35 years, 36－40 years and >40 years, the pregnancy outcomes in each age subgroup were analyzed under different controlled ovarian hyperstimulation protocols.Results:In early-follicular phase long-acting GnRH agonist long protocol group, the final live birth rates of each age subgroup were 39.4% (228/579), 36.1% (135/374), 16.6% (48/290) and 3.0% (4/132); in mid-luteal phase short-acting GnRH agonist long protocol group, live birth rates of each age subgroup were 32.1% (99/308), 20.8% (55/264), 13.0% (45/346) and 7.0% (17/243); in GnRH antagonist protocol group, live birth rates of each age subgroup were 22.8% (26/114), 16.3% (25/153), 11.2% (31/278), and 3.8% (10/261); the live birth rate of each group decreased significantly with the increase of age (all P<0.01). When the age≤35 years old, the fresh cycle live birth rate of the early-follicular phase long-acting GnRH agonist long protocol group was significantly better than those of the other two groups (all P<0.01). The multivariate logistic regression analysis of age and live birth rate of the three controlled ovarian hyperstimulation groups showed age was the independent influence factor ( OR=0.898, 95% CI: 0.873-0.916, P<0.01; OR=0.926, 95% CI: 0.890-0.996, P<0.01; OR=0.901, 95% CI: 0.863-0.960, P<0.01). Conclusions:Age is an independent influencing factor for the prediction of fresh cycle live birth rate in low ovarian response patients. No matter which controlled ovarian hyperstimulation protocol is adopted, the final live birth rate decreases significantly with the increase of women′s age. In addition, the early-follicular phase long-acting GnRH agonist long protocol has the highest fresh cycle live birth rate among all controlled ovarian hyperstimulation groups.
ABSTRACT
Objective:To explore the selection strategy of blastocyst transfer number in freeze-thaw cycle for women over 40 years old, so as to provide reference for reducing twin rate and improving perinatal clinical outcome.Methods:A retrospective analysis was made of 377 patients who underwent freeze-thaw blastocyst transplantation in the reproductive center of Guangdong Maternal and Child Health Hospital from January 2017 to December 2019. They were divided into single blastocyst and double blastocyst transplantatio groups according to the number of blastocyst transplantation. The clinical pregnancy rate, implantation rate, abortion rate, live birth rate, premature delivery rate, twin rate and singleton delivery rate were compared between the two groups.Results:⑴There was no significant difference between two groups regarding the majority of baseline characteristics, including age at retrieval, age at transfer, body mass index (BMI), antral follicle count (AFC), basal follicle stimulating hormone (FSH), anti Mullerian hormone (AMH), endometrial thickness at transfer day, number of oocytes retrieved, Gn starting dose, Gn days, Gn dosage, embryos at cleavage stage and top-quality embryos ( P>0.05). ⑵ There was no significant difference in the rate of implantation, early pregnancy loss, late pregnancy loss and live birth between two groups ( P>0.05). ⑶ The preterm birth rate was higher in the double blastocyst transplantation group compared with the single blastocyst transplantation group, albeit not reaching significant difference (31.7% vs 12.5%, P=0.083). ⑷ The clinical pregnancy rate and the twin pregnancy rate was significantly higher in the double blastocyst transplantation group compared with the single blastocyst transplantation group ( P<0.05). ⑸ The singleton birth rate was significantly lower in the double blastocyst transplantation group compared with the single blastocyst transplantation group (75.61% vs 95.83%, P<0.05). Conclusions:In women ≥40 years old, transferring a single blastocyst can result in live birth rate that is similar as transferring two blastocysts while dramatically reducing the risk of twin pregnancy rate and increasing singleton birth rate.
ABSTRACT
Abstract Patent ductus arteriosus (PDA) is a clinical condition mostly found in premature newborns. Among several medical, surgical and interventional treatment options, extrapleural ligation through a left minithoracotomy is recognized as a safe, efficient and less expensive technique. In fact, it requires short surgical times, grants good exposure of the duct and nearby structures (e.g., thoracic duct, left recurrent laryngeal nerve), and avoids pleural space opening and subsequent pulmonary complications in preterm patients. This approach seems ideal due to its lower costs, especially in developing countries with a high birth rate and limited resources.
Subject(s)
Humans , Infant, Newborn , Thoracotomy/methods , Ductus Arteriosus, Patent/surgery , Ductus Arteriosus, Patent/diagnostic imaging , Pleura/surgery , Infant, Premature , Infant, Newborn, Diseases/surgery , Infant, Newborn, Diseases/diagnostic imaging , LigationABSTRACT
Background: Mortality is important to study population change in the country; infant mortality is considered as principal component balancing the child sex ratio. In this study authors aimed to analyze how mortality rates and child sex ratios are different in urban and rural areas and how its growth statistics are changing over years. Objectives of the study were to quantify infant mortality rates change over time and check the means among mortality indicators.Methods: The study was conducted using secondary data obtained from various issues and reports published by Registrar General and Census Commissioner, India for a period of 10 years from 2006 to 2016. The obtained data on mortality indicators were subjected to basic statistical analysis using percent change and paired t-test.Results: The Infant mortality rate which was reduced by 23 points indicating reduction of 67.65 percent control over a period from 2006 to 2016. Further, results show that, in case of urban mortality, there was significant difference between mortality indicators during study period, the p-value (0.011) was less than level of significance (0.05) so we reject the null hypothesis and it is concluded that there is significant difference between the means of urban mortality indicators over a period of from 2006 to 2016.Conclusions: The infant mortality rate frequently provided as a key indicator of overall the development. There is need for stable child sex ratio; health of children and women are essential for better growth and reaching stable child sex ratio for the ever increasing population.
ABSTRACT
Background: Tuberculosis is an increasing health problem worldwide with around 9.6 billion new cases reported every year. Female genital tuberculosis (FGTB) has a varying incidence ranging from a very low of 0.69% in developed nations to as high as 19% in developing nations like India. The average incidence of infertility due to tuberculosis is 5-10% worldwide.Methods: The study was a hospital based prospective clinical study, from September 2014-2017 with sample size of 355 infertility cases. Endometrial sampling and diagnostic hystero-laparoscopy were used for diagnosis. Endometrial sample subjected for both the test CBNAAT and HPR was used for confirmation of positive patients. Inclusion criteria were, infertile patients diagnosed with genital tuberculosis who were then given treatment. Patients diagnosed to have infertility due to causes other than TB were excluded from the study. Highly suspected cases and those who were willing underwent diagnostic laparoscopy.Results: Out of 355 cases of infertility, 83 were because of genital TB, received treatment out of which 32 conceived. CBNAAT was very sensitive than histopathology or laparoscopy. The live birth rate and conception rate were 20.24% and 38.09 % respectively.Conclusions: CBNAAT is OPD based economical test (free by GOI), very sensitive and picked up more cases than histopathology or laparoscopy. The live birth rate and conception rate were found to be higher than other studies possible due to intervention at an earlier stage of the disease process. This test should be widely used by gynecologist for early detection of genital tuberculosis.